Citrulline Malate (CM)
CM works by powering ATP (major energy source for muscles) production and by eliminating metabolic pollutants such as lactic acid and ammonia from the blood. Citrulline stimulates energy, boosts the immune system and metabolised to form L-arginine. As a result, citrulline helps regulate Nitric Oxide production and detoxifies ammonia; which damages living cells. All exercise results in production of Ammonia.
Malate conditions the recycling of lactate and pyruvate and is part of the Kreb’s cycle; it can supply instant and sustained energy. While the citrulline part of CM acts to increase NO and to eliminate performance inhibiting metabolic toxins, the Malate part keeps our energy cycle going.
CM also aids in recovery. Subsequent to exercise, muscle levels of creatine phosphate are reduced and it takes some time for levels to be replenished. The more creatine phosphate your muscles have the stronger and more able to perform they will be. CM stimulates phosphocreatine recovery after exercise; meaning faster recuperation between workouts. This results it muscles that are primed for growth and ready for your next training session.
CM is best taken on an empty stomach prior to exercise. Additional doses can be taken first thing in the morning upon rising and also before going to sleep.
Because CM can enhance plasma arginine levels, it makes sense to use CM at the optimal times for arginine supplementation.
The minimum dose required for positive effects is reported as being 6g a day. However some studies have used doses as high as 18g a day with remarkable results.
CM is extremely safe and there are no known negative side effects from its use. CM typically produces noticeable results in 15 days or less. This is in regards to performance, but it will immediately begin to work on clearing toxins from the body; promoting energy, and stimulating the immune system. Some people will notice results in as little as 3 to 5 days, but most users will see results in no later than 15 days.
Most of the studies on CM show an increased ability to produce energy through our body’s aerobic energy producing cycle. Strength athletes tend to be more concerned with increasing anaerobic energy which is used for explosive movements. Fortunately, studies clearly show that CM favours the renal reabsorption of bicarbonates and so protects against metabolic acidosis (i.e keeps blood pH in check).
CM is an extremely effective compound for every athlete. Although extremely safe and healthful to use, the manufacturing cost of this product are extremely high, so it may not be worth the money for those who only make it to the gym twice a week or whose training is of a general nature.
For serious and focused athletes CM will prove to be very useful. It can be used on mass building cycles or fat burning/weight loss cycles. Bodybuilders dieting down for contests can make great use of this supplement. During contest time, bodybuilders are consuming fewer calories and training more frequently. Their bodies are also under the most amount of stress. CM can help provide the needed energy to train hardest when bodybuilders need it the most and make cardio sessions much easier; leading to the increased ability to burn fat and keep muscle.
Also, bodybuilders consume a tremendous amount of protein year round, but more so in preparation for contest; increased protein metabolism coupled with the catabolic stress of contest preparation can lead to higher than usual amounts of ammonia. CM will aid by keeping the body free and pure of this damaging metabolic waste product.
Boxers, soccer players, sprinters and cyclists can also benefit from a greater ability to produce more energy for their respective sporting events and training sessions.
Studies show that citrulline is better absorbed than arginine, and since it is a precursor to arginine, plasma levels of arginine from oral citrulline are elevated. Once arginine on its own is assimilated and goes through the liver, a great portion of it is degraded.
In comparison, citrulline is not cleared by the liver and is taken up by the kidneys and other tissues and then converts to arginine. In regards to Nitric Oxide (NO), citrulline has shown to be more potent at reversing the negative actions of Nitric Oxide Synthase (NOS) Inhibitors, which are enzymes that prevent the synthesis of Nitric Oxide.