Dimethylaminoethanol is also known as dimethylethanolamine (DMAE and DMEA respectively)
Dimethylaminoethanol is related to choline and may be a biochemical precursor to the neurotransmitter acetylcholine, although this conclusion has been disputed. It is commonly believed that dimethylaminoethanol is methylated to produce choline in the brain, but this has been shown not to be the case. It is known that dimethylaminoethanol is processed by the liver into choline; however, the choline molecule is charged and cannot pass the ‘blood–brain barrier’. In the brain, DMAE is instead bound to phospholipids in place of choline to produce phosphatidyl-dimethylaminoethanol. This is then incorporated into nerve membranes, increasing fluidity and permeability, and acting as an antioxidant*.
Short-term studies have shown an increase in vigilance and alertness with a positive influence on mood following administration of DMAE, vitamins, and minerals in individuals suffering from borderline emotional disturbance.
DMAE is a compound that is known as a mind health compound. It does this by reducing buildup of what is known as the ‘age pigment’, beta-amyloid, which impairs cognitive function and is implicated in the cognitive decline with age.
It can also protect neurons and other cells from harmful effects of certain types of oxidation by embedding itself in the structure of the cell and acting as an anti-oxidant, as well as sustaining metabolic processes in the body through a process known as ‘methyl donation’*.
DMAE is also found in various face and body creams, and can tighten and tone skin quality.
DMAE is a Choline molecule with one less methyl group. It is the active component of Centrophenoxine/Lucidril, a pharmaceutical designed for cognitive health in the elderly.